Comparative efficacy of leukotriene modifier and inhaled corticosteroids in the complex treatment of steroid-naive patients with bronchial asthma combined with chronic obstructive pulmonary disease with neutrophilic type of inflammation

The aim: to compare the efficacy and tolerability of leukotriene modifier inhaled corticosteroids in combination with long-acting β2-agonist formoterol steroid-naive patients asthma combined COPD neutrophilic inflammation. Materials methods. After obtaining written consent, 30 a number blood neutrophils >4000/μl were randomized (1:1): group I – received fixed budesonide/formoterol 160/4.5 μg/1 inhalation twice daily as basic therapy; II montelukast 1 tab. (10 mg) once 12 mcg/dose daily. duration therapy was weeks. General clinical methods, control questionnaires, questionnaire, physical tolerance evaluation (6-minute walk test), pulmonary function tests, quality life assessment performed all before after treatment course studied. Results. improved symptoms significantly (P < 0.05) increased total ACT score, decreased average ACQ shortness breath (mMRC scale), symptoms. PFT indices 0.05), bronchoobstruction at level large, medium small bronchi reduced. Physical improved. There no statistically significant dynamics studied patient II. both groups showed tendency improve their life. In group, there decrease activity limitations SGRQ score. Conclusions. corticosteroid/formoterol has proven be more effective than or